Reactome releases knowledgebase version 53
Reactome knowledgebase 53 features updates to signal transduction pathways, new immune system and disease pathways, revised topics and new pathway illustrations.
Reactome is a free, open-source, curated and peer reviewed pathway database. Our goal is to provide intuitive bioinformatics tools for the visualisation, interpretation and analysis of pathway knowledge to support basic research, genome analysis, modeling, systems biology and education. Version 53 of Reactome, released on 2 July 2015. features updates to signal transduction pathways, new immune system and disease pathways, revised topics and new pathway illustrations.
Signal transduction
Signal transduction pathways have been updated to include:
- mTOR signaling
- MAPK6/MAPK4 signaling
- the RAF/MAPK pathway
- deactivation of the beta-catenin transactivating complex.
Immune system
New immune system pathways include:
- the TNFRSF mediated non-canonical NF-kB pathway and
- immunoregulatory interactions between Lymphoid and a non-Lymphoid cells.
Disease
New disease pathways in this version:
Revised topics
Other revised topics in version 53 include:
- Cellular responses to stress (Macroautophagy)
- Chromatin organization (HDMs demethylate histones)
- developmental biology (LGI-ADAM interactions).
Illustrations
New pathway Illustrations are available for:
- cellular senescence
- oncogene-induced senescence
- oxidative-stress-induced senescence
- DNA-damage/telomere-stress-induced senescence
- senescence-associated secretory phenotype (SASP).
Acknowledgements
With thanks to our external reviewers: Alexander Barrow, Sharon A Tooze, Vincent Harley, Richard Hopkinson, Simon Mathien, Dies Meijer,Sylvain Meloche, Ugo Moens, Karobi Moitra, Akhil Rajput, Robert Roskoski, Christopher Schofield, Ole-Morten Seternes, Mathilde Soulez, Dorothe Spillmann, David J Timson, Richard Virgen-Slane, Louise Walport, Carl F Ware, and Fried Zwartkruis
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