Latest Release of the Single Cell Expression Atlas

The latest release of Single Cell Expression Atlas (SCEA) is now live. This includes more RNA transcriptomes of cells at the single cell resolution, including new species – Xenopus tropicalis (western clawed frog). We’ve also included many new datasets investigating Drosophila melanogaster (fruit fly) and Danio rerio (zebrafish) expanding the representation of key model organisms within the knowledgebase.

New datasets

As one of the larger resources for single-cell expression data, now there are 355 single-cell RNA-Seq experiments, consisting of 10,505,726 cells across 21 different species to explore in SCEA. As always, we aim to provide high-quality datasets carefully curated by our scientific curators and visualisation of cell clustering and gene expression profiling for cells passed by our standard single-cell analysis pipeline.

New species

Welcome to western clawed frog (Xenopus tropicalis), who has joined the family of SCEA species as well from this release! We are continuing our commitment to displaying data from a range of different species. Investigate how neuronal differentiation during regeneration happens in this little creature.

Key model organisms

The representation of key model organisms is expanded with an increased number of studies in Drosophila melanogaster (fruit fly) and Danio rerio (zebrafish).

Highlights include:

• Drosophila melanogaster female late third instar larval gonads single-cell RNA-Seq (scRNA-Seq) profiling
• Modular transcriptional programs separately define axon and dendrite connectivity
• Single-cell RNA sequencing of zebrafish thyroid cells
• Cell state diversity promotes metastasis through heterotypic cluster formation in melanoma [scRNA-Seq]
• Single-cell RNA sequencing of the cut and uncut caudal fin of zebrafish larvae
• The Single Cell Transcriptomic Landscape of Early Human Diabetic Nephropathy