IntAct release 165 highlight: the SH3 interactome
With release 165, IntAct now offers 314,019 binary interactions from 6485 manually curated publications.
With release 165, IntAct now offers 314,019 binary interactions from 6485 manually curated publications.
IntAct, the open-source protein interaction database, derives its entries from literature curation or direct user submissions. The data are freely available, and you can find the latest release on the FTP site: ftp://ftp.ebi.ac.uk/pub/databases/intact/current/
Dataset of the month
InAct features data from "SH3 interactome conserves general function over specific form," by Xin et al., Mol Syst Biol. 2013; 9: 652.
Src homology 3 (SH3) domains bind peptides to mediate protein–protein interactions that assemble and regulate dynamic biological processes. The authors suggest a model of network evolution where general function of the SH3 domain network is conserved over its specific form.
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